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Investigation on the efficiency of Brucea javanica oil emulsion injection with chemotherapy for treating malignant pleural effusion: A meta-analysis of randomized controlled trials

Authors :
Rui Shi
Zhishan Wu
Haojia Wang
Jingyuan Zhang
Fanqin Zhang
Antony Stalin
Meilin Chen
Jiaqi Huang
Yiyan Zhai
Qianqian Zhang
Pengyun Liu
Jiarui Wu
Bin Sun
Chunfang Wu
Source :
Frontiers in Pharmacology, Vol 13 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Introduction: Systematic evaluation of the clinical efficacy and safety of Brucea javanica oil emulsion injection (BJOEI) in combination with chemotherapy in the treatment of malignant pleural effusion (MPE).Methods: The study searched CNKI, Wanfang database, VIP database, SinoMed, PubMed, Embase, the Cochrane Library, and the Web of Science database and retrieved randomized controlled trials (RCTs) on the treatment of MPE with BJOEI in combination with chemotherapy from seven electronic databases from inception to 31 March 2022. Meta-analysis and sensitivity analysis were performed using Revman 5.4 and Stata 13.0 software.Results: Ultimately, 30 RCTs with 2035 patients were included, including 1002 cases in the control group and 1033 cases in the treatment group. The results of the meta-analysis showed that the overall efficacy rate of BJOEI combined with chemotherapy was higher in the treatment of MPE compared with chemotherapy alone (RR = 1.45, 95%CI: 1.36–1.54, p < 0.00001). And it could improve the Karnofsky (KPS) score (RR = 1.54, 95%CI: 1.41–1.68, p < 0.00001), reduce adverse reactions such as fever (RR = 0.82, 95%CI:0.60–1.12), chest pain (RR = 0.90, 95%CI: 0.67–1.21), gastrointestinal reactions (RR = 0.70, 95%CI: 0.57–0.87, p < 0.005), and leukopenia (RR = 0.51, 95%CI: 0.43–0.61, p < 0.00001).Conclusion: BJOEI combined with chemotherapy has better clinical efficacy than chemotherapy alone in the treatment of MPE. It can further improve KPS score, improve patients’ quality of life, and reduce the occurrence of adverse reactions. However, the conclusions of this study need to be confirmed by further randomized, double-blind, controlled trials with large sample size, reasonable design, and strict implementation.

Details

Language :
English
ISSN :
16639812
Volume :
13
Database :
Directory of Open Access Journals
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
edsdoj.30331eafb32c4cc29fd1ed106b1d1547
Document Type :
article
Full Text :
https://doi.org/10.3389/fphar.2022.998218