Back to Search
Start Over
DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer
- Source :
- Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
- Publication Year :
- 2022
- Publisher :
- BMC, 2022.
-
Abstract
- Highlights 1. DUB1 is an important modulator of Hippo signaling in gastric cancer. 2. DUB1 expression is elevated in human gastric cancer samples and correlates with poor survival in gastric cancer. 3. DUB1 facilitates gastric cancer progression via the Hippo/TAZ axis. 4. DUB1 associates with TAZ and directly inhibits YAP polyubiquitination and degradation.
Details
- Language :
- English
- ISSN :
- 17569966
- Volume :
- 41
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Experimental & Clinical Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2fdc017c5a9c4d9aaef1fa5cec6b80ce
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13046-022-02410-5