The consistent application of antimicrobial and detoxifying agents with chronic apical periodontitis endodontic treatment (clinical and experimental study)

In this research an experiment has been studied of characteristics of sodium hypochlorite solutions of different concentrations used for medical treatment of root canal system to justify the choice of the most effective concentration and to study the possibility of combination with antimicrobials – metronidazole and detoxifying agent for treating chronic periodontitis – polyoxidonium. A significant reduction in the level of microbial load of root canals during endodontic treatment has been established. The pilot cytomorphological study showed a beneficial effect of 0.5% solution of sodium hypochlorite, metronidazole and polyoxidonium on the tooth cytostructure.