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Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)

Authors :
Raimundo Gonçalves de Oliveira Júnior
Christiane Adrielly Alves Ferraz
Juliane Cabral Silva
Ana Paula de Oliveira
Tâmara Coimbra Diniz
Mariana Gama e Silva
Lucindo José Quintans Júnior
Ana Valéria Vieira de Souza
Uiliane Soares dos Santos
Izabel Cristina Casanova Turatti
Norberto Peporine Lopes
Vitor Prates Lorenzo
Jackson Roberto Guedes da Silva Almeida
Source :
Molecules, Vol 22, Iss 6, p 900 (2017)
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

Medicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p < 0.05). The same was observed in both phases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of KATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine.

Details

Language :
English
ISSN :
14203049
Volume :
22
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.2fb091e7f8dc48ae98ed670cb153116a
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules22060900