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Clinical role of genetic testing for the Brugada syndrome overlapping with arrhythmogenic cardiomyopathy

Authors :
Joo Hee Jeong
Hyoung Seok Lee
Yun Young Choi
Yun Gi Kim
Jaemin Shim
Jin Ha Hwang
Seung Gyu Yun
Yun Jung Cho
Young-Hoon Kim
Jong-Il Choi
Source :
International Journal of Arrhythmia, Vol 25, Iss 1, Pp 1-11 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background Brugada syndrome (BrS) and arrhythmogenic cardiomyopathy (ACM) are inherited cardiac diseases that may predispose to ventricular arrhythmia. Although overlapping features between BrS and ACM have been demonstrated previously, it remains to be determined whether genetic testing for ACM-related genes is needed in BrS probands. Method Based on a single-center, retrospective registry of BrS, we aimed to verify genetic profiles of BrS using a next-generation sequencing panel, and further analyzed genetic testing of ACM-related variants in Brugada phenotypes. Results Among a total of 119 Brugada phenotypes, 114 patients (95.8%) were male and the mean age of onset was 43.6 years. Genetic variants were identified in 25 of the 42 patients who underwent genetic testing. Fifteen patients had BrS-related genotypes, including SCN5A in 6 patients, and non-SCN5A genes in 9 patients (SCN10A, HCN4, SCN3B, and KCNE3). Nineteen patients underwent additional genetic testing with cardiomyopathy panel, which revealed ACM-related genotypes (2 PKP2, 1 DSG2, 1 TMEM43, 1 JUP, and 1 DSP) present in 6 patients (31.5%). None of the patients had structural or electrocardiographic features that fulfilled the diagnostic criteria for ACM. Conclusions In clinical setting, ACM-related genes were identified in a significant proportion of Brugada phenotypes, supporting the argument that genetic testing of ACM overlapping is needed. Follow-up imaging studies should be considered to monitor if the disease progresses to ACM.

Details

Language :
English
ISSN :
24661171
Volume :
25
Issue :
1
Database :
Directory of Open Access Journals
Journal :
International Journal of Arrhythmia
Publication Type :
Academic Journal
Accession number :
edsdoj.2f9176e0aa6f4933915e75fa69399776
Document Type :
article
Full Text :
https://doi.org/10.1186/s42444-024-00121-w