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A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

Authors :
Chiara Ghezzi
Alicia Wong
Bao Ying Chen
Bernard Ribalet
Robert Damoiseaux
Peter M. Clark
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Many cancer cells have increased glucose consumption compared to normal cells, a feature that can be exploited therapeutically. Here, the authors carry out a chemical screen and identify compounds that selectively blocks glucose metabolism in non-small-cell lung cancer cell lines.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2eda619824de42219eeab1b51ef3beb0
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13334-8