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Serum miR-342-3p Acts as a Biomarker for Systemic Lupus Erythematosus and Participates in the Disease Progression
- Source :
- Clinical, Cosmetic and Investigational Dermatology, Vol Volume 16, Pp 39-46 (2023)
- Publication Year :
- 2023
- Publisher :
- Dove Medical Press, 2023.
-
Abstract
- Min You, Long Zhang, Junxiao Ding Department of Dermatology, Affiliated Hospital of Gansu Medical College, Pingliang, Gansu, People’s Republic of ChinaCorrespondence: Junxiao Ding, Department of Dermatology, Affiliated Hospital of Gansu Medical College, No. 296, Kongtong East Road, Kongtong District, Pingliang, Gansu, 744000, People’s Republic of China, Tel +86-0933-8613787, Fax +86-0933-8613787, Email junxiaodinggs@163.comPurpose: The aim of this study was to investigate the diagnostic ability and prognostic value of miR-342-3p in SLE patients by detecting the expression level of serum miR-342-3p in SLE patients.Patients and Methods: The expression level of serum miR-342-3p in all subjects was determined by qRT-PCR technology, and the correlation of miR-342-3p with SLEDAI scores was evaluated using Spearman correlation coefficient. The diagnostic value of miR-342-3p in SLE was assessed using ROC curve. The prognostic value of miR-342-3p in SLE patients was analyzed by Kaplan–Meier survival curve and multivariate COX regression.Results: The qRT-PCR results showed that the expression level of serum miR-342-3p in SLE patients was significantly lower than that in healthy controls (P < 0.001). Serum miR-342-3p expression level was negatively correlated with SLEDAI scores (r = - 0.810, P < 0.001). The ROC curve suggested that serum miR-342-3p expression level was discriminative between SLE patients and healthy controls. Survival analysis results indicated that SLE patients with low serum miR-342-3p expression had a higher probability of poor prognosis of SLE (Log rank P = 0.003).Conclusion: The expression level of serum miR-342-3p was valuable in the diagnosis of SLE. Meanwhile, the low expression level of serum miR-342-3p was associated with the poor prognosis of SLE.Keywords: miR-342-3p, systemic lupus erythematosus, diagnosis, prognosis
- Subjects :
- mir-342-3p
systemic lupus erythematosus
diagnosis
prognosis
Dermatology
RL1-803
Subjects
Details
- Language :
- English
- ISSN :
- 11787015
- Volume :
- ume 16
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical, Cosmetic and Investigational Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2ec57dae5fe44b43b7de39be05b4abb1
- Document Type :
- article