Back to Search
Start Over
Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis
- Source :
- Frontiers in Physiology, Vol 9 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- Background: There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis.Methods: Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis.Results: Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included. The pooled HR of OS was 1.13 (95% CI: 0.66–1.95). In subgroup analysis, no significant association between c-Myc and CRC prognosis was found in the studies either from Western countries (HR: 0.87, 95% CI: 0.68–1.10) or Asian countries (HR: 1.89, 95% CI: 0.62–5.77). HRs were 0.86 (95% CI: 0.38–1.94) and 1.57 (95% CI: 0.73–3.39) for the studies using univariate analysis and multivariate analysis, respectively. HR from the studies that examined DNA level was significantly different (HR: 2.05, 95% CI: 1.22–3.46); while that about RNA level or protein level was not significantly different.Conclusion: c-Myc was not associated with CRC prognosis in this meta-analysis. However, the conclusion is preliminary and should be examined in future studies.
- Subjects :
- c-Myc
colorectal cancer
prognosis
biomarker
meta-analysis
Physiology
QP1-981
Subjects
Details
- Language :
- English
- ISSN :
- 1664042X
- Volume :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2e77f555a4494ec49837afc748a2f731
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fphys.2018.01549