Expression of peptidylarginine deiminase 2 and 4 in malignant mesothelioma and its clinical significance

Authors :: GAN Yihan, SHEN Wei, CHEN Yitong, YAN Kaili, HU Shuaiyue, JIANG Zhaoqiang, YING Shibo
Source :: Jichu yixue yu linchuang, Vol 43, Iss 7, Pp 1117-1121 (2023)
Publication Year :: 2023
Publisher :: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2023.
Abstract: Objective To investigate the expression of peptidylarginine deiminase 2 and 4 (PAD2 and PAD4) in malignant mesothelioma (MM), their correlation with citrullinated proteins and clinical significance. Methods The pathological samples of 45 cases of MM in Zhejiang province from 2014 to 2021 were collected retrospectively for constructing paraffin-embedded tissue microarray. The expressions of PAD2 and PAD4 in tumor and paired adjacent tissues were detected by immunohistochemistry and the clinical significance was analyzed by utilizing bioinformatics database. Results The expressions of PAD2 and PAD4 in MM tissues were significantly higher than those in adjacent tissues (P

Subjects :: malignant mesothelioma
peptidylarginine deiminase 2
peptidylarginine deiminase 4
citrullination
Medicine

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