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Environmental Enrichment Attenuates Morphine-Induced Conditioned Place Preference and Locomotor Sensitization in Maternally Separated Rat Pups

Authors :
Soheyla Khalaji
Imanollah Bigdeli
Raheb Ghorbani
Hossein Miladi-Gorji
Source :
Basic and Clinical Neuroscience, Vol 9, Iss 4, Pp 241-250 (2018)
Publication Year :
2018
Publisher :
Iran University of Medical Sciences, 2018.

Abstract

Introduction: This study investigated the effect of the environmental enrichment during adolescence on morphine-induced Conditioned Place Preference (CPP) and locomotor sensitization in maternally separated male and female rat pups. Methods: Male Wistar rats were allowed to mate with female virgin Wistar rats. Pups were separated from them 3 hours per day during 2–14 days postnatal. All pups were weaned at 21 Postnatal Day (PND) and reared in standard environment or enriched environment from 21 to 50 PND with litter-mates of the same sex. The CPP and behavioral sensitization to morphine were assessed by an unbiased place conditioning paradigm and open filed method. Results: The results showed that the maternal separation enhanced morphine-induced CPP in both sexes, locomotor sensitization in male pups and tolerance to morphine-induced motor activity in female pups during adolescence. While, male and female pups reared in an EE exhibited a decrease in morphine-induced CPP, locomotor sensitization and tolerance induced by maternal separation compared to their control pups. Conclusion: Access to enriched environment during adolescence may have a protective effect against morphine-induced reward, locomotor sensitization and tolerance in adolescent male and female rats following maternal separation.

Details

Language :
English
ISSN :
2008126X and 22287442
Volume :
9
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Basic and Clinical Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.2e3cbd7449e4f7ebb2b7524577bd6e5
Document Type :
article