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Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
- Source :
- Molecules, Vol 17, Iss 5, Pp 5497-5507 (2012)
- Publication Year :
- 2012
- Publisher :
- MDPI AG, 2012.
-
Abstract
- A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.
Details
- Language :
- English
- ISSN :
- 14203049 and 04538870
- Volume :
- 17
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2e2c756af0d045388703262bfa020eb1
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules17055497