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Muscle Network Connectivity Study in Diabetic Peripheral Neuropathy Patients

Authors :
Isabel Junquera-Godoy
José Luís Martinez-De-Juan
Gemma González-Lorente
José Miguel Carot-Sierra
Julio Gomis-Tena
Javier Saiz
Silvia García-Blasco
Isabel Pertusa-Mazón
Esther Soler-Climent
Gema Prats-Boluda
Source :
Sensors, Vol 24, Iss 15, p 4954 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Diabetic peripheral neuropathy (DPN) is a prevalent complication of chronic diabetes mellitus and has a significant impact on quality of life. DPN typically manifests itself as a symmetrical, length-dependent sensorimotor polyneuropathy with severe effects on gait. Surface electromyography (sEMG) is a valuable low-cost tool for assessing muscle activation patterns and precise identification of abnormalities. For the present study, we used information theory methods, such as cross-correlation (CC), normalized mutual information (NMI), conditional granger causality (CG-Causality), and transfer entropy (TE), to evaluate muscle network connectivity in three population groups: 33 controls (healthy volunteers, CT), 10 diabetic patients with a low risk of DPN (LW), and 17 moderate/high risk patients (MH). The results obtained indicated significant alterations in the intermuscular coupling mechanisms due to diabetes and DPN, with the TE group showing the best performance in detecting differences. The data revealed a significant increase in information transfer and muscle connectivity in the LW group over the CT group, while the MH group obtained significantly lower values for these metrics than the other two groups. These findings highlight the sEMG coupling metrics’ potential to reveal neuromuscular mechanisms that could aid the development of targeted rehabilitation strategies and help monitor DPN patients.

Details

Language :
English
ISSN :
24154954 and 14248220
Volume :
24
Issue :
15
Database :
Directory of Open Access Journals
Journal :
Sensors
Publication Type :
Academic Journal
Accession number :
edsdoj.2e1ed3947410489080263afcdce05c5b
Document Type :
article
Full Text :
https://doi.org/10.3390/s24154954