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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Authors :
Akul Singhania
Christine M. Graham
Leona Gabryšová
Lúcia Moreira-Teixeira
Evangelos Stavropoulos
Jonathan M. Pitt
Probir Chakravarty
Annika Warnatsch
William J. Branchett
Laura Conejero
Jing-Wen Lin
Sophia Davidson
Mark S. Wilson
Gregory Bancroft
Jean Langhorne
Eva Frickel
Abdul K. Sesay
Simon L. Priestnall
Eleanor Herbert
Marianna Ioannou
Qian Wang
Ian R. Humphreys
Jonathan Dodd
Peter J. M. Openshaw
Katrin D. Mayer-Barber
Dragana Jankovic
Alan Sher
Clare M. Lloyd
Nicole Baldwin
Damien Chaussabel
Venizelos Papayannopoulos
Andreas Wack
Jacques F. Banchereau
Virginia M. Pascual
Anne O’Garra
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lung, which represents a global profile of host-pathogen immune responses.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2de9148c41624ebdb261719be7a52d90
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-10601-6