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Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
- Source :
- eJHaem, Vol 4, Iss 4, Pp 1105-1109 (2023)
- Publication Year :
- 2023
- Publisher :
- Wiley, 2023.
-
Abstract
- Abstract UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF‐TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF‐TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
Details
- Language :
- English
- ISSN :
- 26886146
- Volume :
- 4
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- eJHaem
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2d9d94c1c90646a8aaf70629c552d1da
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/jha2.808