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Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?

Authors :
Marcela Muñoz-Torrico
Adrian Rendon
Rosella Centis
Lia D'Ambrosio
Zhenia Fuentes
Carlos Torres-Duque
Fernanda Mello
Margareth Dalcolmo
Rogelio Pérez-Padilla
Antonio Spanevello
Giovanni Battista Migliori
Source :
Jornal Brasileiro de Pneumologia, Vol 42, Iss 5, Pp 374-385
Publisher :
Sociedade Brasileira de Pneumologia e Tisiologia.

Abstract

ABSTRACT The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the "post-tuberculosis treatment" phase, which will potentially affect several million cases every year. We carried out a non-systematic literature review based on a PubMed search using specific keywords (various combinations of the terms "tuberculosis", "rehabilitation", "multidrug-resistant tuberculosis", "pulmonary disease", "obstructive lung disease", and "lung volume measurements"). The reference lists of the most important studies were retrieved in order to improve the sensitivity of the search. Manuscripts written in English, Spanish, and Russian were selected. The main areas of interest were tuberculosis sequelae following tuberculosis diagnosis and treatment; "destroyed lung"; functional evaluation of sequelae; pulmonary rehabilitation interventions (physiotherapy, long-term oxygen therapy, and ventilation); and multidrug-resistant tuberculosis.The evidence found suggests that tuberculosis is definitively responsible for functional sequelae, primarily causing an obstructive pattern on spirometry (but also restrictive and mixed patterns), and that there is a rationale for pulmonary rehabilitation. We also provide a list of variables that should be discussed in future studies on pulmonary rehabilitation in patients with post-tuberculosis sequelae.

Details

Language :
English, Portuguese
ISSN :
18063756
Volume :
42
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Jornal Brasileiro de Pneumologia
Publication Type :
Academic Journal
Accession number :
edsdoj.2d89c6687e234dd7b49a00c20d5861db
Document Type :
article
Full Text :
https://doi.org/10.1590/S1806-37562016000000226