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Effectiveness and safety of immunoadsorption as a rescue treatment of inflammatory myopathies: report of three cases and literature review

Authors :
Jasper F. Nies
Claudia Hendrix
Malte P. Bartram
Ryan Spear
Henning Hagmann
Thomas Benzing
Torsten Kubacki
Source :
Therapeutic Advances in Musculoskeletal Disease, Vol 16 (2024)
Publication Year :
2024
Publisher :
SAGE Publishing, 2024.

Abstract

Idiopathic inflammatory myopathy (IIM) summarizes rare, systemic autoimmune conditions primarily characterized by inflammatory damage to the skeletal muscle. Although primary damage occurs to the muscle, these IIM-related conditions involve other organs, including the skin, lungs, upper gastrointestinal tract, joints, and heart. While many patients have an adequate response to immunosuppressive treatment, some patients develop rapidly progressive and treatment-resistant life-threatening courses. Treatment-resistant IIM is challenging for the treating physician and requires interdisciplinary and individualized treatment approaches. Extracorporeal therapy is one option for rescue therapy, with immunoadsorption (IA) having proven more effective than plasma exchange regarding the removal of circulating antibodies. Despite its efficacy and desirable safety profile, the clinical value of IA use in IIM is understudied with no controlled trials reported. Here, we present a review of the current knowledge regarding the management of treatment-resistant IIM and the cases of three patients with treatment-resistant IIM (two with dermatomyositis and one with immune-mediated necrotizing myopathy) who have successfully been treated with IA. All patients responded well to the therapy and experienced no IA-related complications. Taken together, we found IA to be a safe and effective treatment option in treatment-resistant IIM.

Details

Language :
English
ISSN :
17597218 and 1759720X
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Therapeutic Advances in Musculoskeletal Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.2d7b5c07d2c4e7bafbaebec18ef4560
Document Type :
article
Full Text :
https://doi.org/10.1177/1759720X241250238