Research progress on the role of TRIB3 in obesity pathogenesis

Tribbles homolog 3(TRIB3,TRB3) is a kind of protein kinase inhibitors involved in a variety of biological processes like apoptosis, stress response, transcription and transcriptional regulation. Obesity is a chronic metabolic disease caused by many factors including lifestyle, endocrine and drug factors. Abnormal expression of TRIB3 in vivo may be involved in the development of obesity, with expansion of adipose tissue and visceral fat leading to metabolic disorders, organ dysfunction, male infertility, various chronic diseases, and increased mortality. Therefore, exploring the mechanism of TRIB3 in obesity may provide new ideas for the diagnosis and treatment of obesity.