Back to Search
Start Over
Sodium–glucose cotransporters: Functional properties and pharmaceutical potential
- Source :
- Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 770-782 (2020)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Abstract Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.
Details
- Language :
- English
- ISSN :
- 20401124 and 20401116
- Volume :
- 11
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Diabetes Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2d4cb81793024764b14e18e9f4187f80
- Document Type :
- article
- Full Text :
- https://doi.org/10.1111/jdi.13255