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Engineering Tough and Elastic Polyvinyl Alcohol‐Based Hydrogel with Antimicrobial Properties

Authors :
Avijit Baidya
Annabella Budiman
Saumya Jain
Yavuz Oz
Nasim Annabi
Source :
Advanced NanoBiomed Research, Vol 4, Iss 9, Pp n/a-n/a (2024)
Publication Year :
2024
Publisher :
Wiley-VCH, 2024.

Abstract

Hydrogels have been extensively used for tissue engineering applications due to their versatility in structure and physical properties, which can mimic native tissues. Although significant progress has been made toward designing hydrogels for soft tissue repair, engineering hydrogels that resemble load‐bearing tissues is still considered a great challenge due to their specific mechanophysical demands. Herein, microporous, tough, yet highly compressible poly(vinyl alcohol) (PVA)‐based hydrogels are reported for potential applications in repairing or replacing different load‐bearing tissues. The synergy of freeze‐thawing and the Hofmeister effect, which controlled the spatial arrangement and aggregation of polymer chains, facilitated the formation of microstructured frameworks with tunable porosity. While the maximum mechanical strength, toughness, and stretchability of the engineered hydrogel were ≈390 kPa, ≈388 kJ m−3, and ≈170%, respectively, Young's modulus based on compression testing wasfound to be in the range of ≈0.02–0.30 MPa, highlighting the all‐in‐one mechanically enriched nature of the hydrogel. Furthermore, the minimal swelling and degradation rate of the engineered hydrogel met the specific requirements for load‐bearing tissues. Finally, excellent antibacterial resistance as well as in vitro biocompatibility of the hydrogel demonstrates its potential for the replacement of load‐bearing tissues.

Details

Language :
English
ISSN :
26999307
Volume :
4
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Advanced NanoBiomed Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2d48a48f1f2c4e98b6f7bdd00cf154e4
Document Type :
article
Full Text :
https://doi.org/10.1002/anbr.202300173