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Alterations in gut microbiota and metabolite profiles in patients with infantile cholestasis
- Source :
- BMC Microbiology, Vol 23, Iss 1, Pp 1-12 (2023)
- Publication Year :
- 2023
- Publisher :
- BMC, 2023.
-
Abstract
- Abstract Background Infantile cholestasis (IC) is the most common hepatobiliary disease in infants, resulting in elevated direct bilirubin levels. Indeed, hepatointestinal circulation impacts bile acid and bilirubin metabolism. This study evaluates changes in the gut microbiota composition in children with IC and identifies abnormal metabolite profiles associated with microbial alterations. Results The gut microbiota in the IC group exhibits the higher abundance of Veillonella, Streptococcus and Clostridium spp. (P
Details
- Language :
- English
- ISSN :
- 14712180
- Volume :
- 23
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- BMC Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2d044d7a605472a8d4c6c2736c5a558
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12866-023-03115-1