Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer

Background and purpose: At present, gastric cancer is still an important cause of cancer death, and its postoperative recurrence is the main factor leading to the low survival rate of gastric cancer. The purpose of this study was to investigate the relationship between early and late postoperative recurrence and metastasis and clinicopathological features in patients with gastric cancer in order to improve the prognosis of gastric cancer. Methods: The clinicopathological data of 188 patients with recurrent and metastatic gastric cancer after radical operation in Zhejiang Cancer Hospital from January 2014 to January 2016 were analyzed retrospectively. The clinicopathological characteristics of patients with early recurrence and metastasis (≤2 years) and late recurrence and metastasis (>2 years) were compared. Results: Among the 188 patients, 126 patients had early recurrence and 62 patients had late recurrence. The overall median time of recurrence was 18 months after operation. Recurrence site, lymph node metastasis, serosa infiltration, no preoperative neoadjuvant chemotherapy, no postoperative adjuvant chemotherapy and poor differentiation are independent risk factors for early postoperative recurrence of gastric cancer. Conclusion: The location of recurrence, preoperative neoadjuvant chemotherapy, postoperative adjuvant chemotherapy, lymph node metastasis, depth of invasion and degree of tissue differentiation are related to postoperative recurrence.