Back to Search Start Over

Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection

Authors :
Wei-Jiun Tsai
Yi-Hsin Lai
Yong-An Shi
Michal Hammel
Anthony P. Duff
Andrew E. Whitten
Karyn L. Wilde
Chun-Ming Wu
Robert Knott
U-Ser Jeng
Chia-Yu Kang
Chih-Yu Hsu
Jian-Li Wu
Pei-Jane Tsai
Chuan Chiang-Ni
Jiunn-Jong Wu
Yee-Shin Lin
Ching-Chuan Liu
Toshiya Senda
Shuying Wang
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Structural and mutational analyses reveal interactions between NAD+-glycohydrolase and Streptolysin O critical for Group A Streptococcus virulence, validated in a murine infection model.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.2cd8522dbd71452f8c5716972482d2f5
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04502-0