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Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects

Authors :
Gao YM
Pei Y
Zhao FF
Wang L
Source :
Cancer Management and Research, Vol Volume 15, Pp 1323-1337 (2023)
Publication Year :
2023
Publisher :
Dove Medical Press, 2023.

Abstract

Yi-Ming Gao,1 Yan Pei,1 Fei-Fei Zhao,2 Ling Wang1 1Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Ling Wang, Tel +86031188603682, Email wangling2016uw@126.comAbstract: Osteosarcoma is an extremely malignant tumor, and its pathogenesis is complex and remains incompletely understood. Most cases of osteosarcoma are accompanied by symptoms of bone loss or result in pathological fractures due to weakened bones. Enhancing the survival rate of osteosarcoma patients has proven to be a long-standing challenge. Numerous studies mentioned in this paper, including in-vitro, in-vivo, and in-situ studies have consistently indicated a close association between the symptoms of bone loss associated with osteosarcoma and the presence of osteoclasts. As the sole cells capable of bone resorption, osteoclasts participate in a malignant cycle within the osteosarcoma microenvironment. These cells interact with osteoblasts and osteosarcoma cells, secreting various factors that further influence these cells, disrupting bone homeostasis, and shifting the balance toward bone resorption, thereby promoting the onset and progression of osteosarcoma. Moreover, the interaction between osteoclasts and various other cells types, such as tumor-associated macrophages, myeloid-derived suppressor cells, DCs cells, T cells, and tumor-associated fibroblasts in the osteosarcoma microenvironment plays a crucial role in disease progression. Consequently, understanding the role of osteoclasts in osteosarcoma has sparked significant interest. This review primarily examines the physiological characteristics and functional mechanisms of osteoclasts in osteosarcoma, and briefly discusses potential therapies targeting osteoclasts for osteosarcoma treatment. These studies provide fresh ideas and directions for future research on the treatment of osteosarcoma.Keywords: osteosarcoma, osteoclasts, bone remodeling, osteoimmunology, bone microenvironment

Details

Language :
English
ISSN :
11791322
Volume :
ume 15
Database :
Directory of Open Access Journals
Journal :
Cancer Management and Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2cd3f9b819ce4be4ad03ee788aacd4a2
Document Type :
article