Relevance of polymorphisms in MC4R and BDNF in short normal stature

Authors :: Nikolas Herrfurth
Anna-Lena Volckmar
Triinu Peters
Gunnar Kleinau
Anne Müller
Cigdem Cetindag
Laura Schonnop
Manuel Föcker
Astrid Dempfle
Stefan A. Wudy
Struan F. A. Grant
Thomas Reinehr
Diana L. Cousminer
Johannes Hebebrand
Heike Biebermann
Anke Hinney
Source :: BMC Pediatrics, Vol 18, Iss 1, Pp 1-12 (2018)
Publication Year :: 2018
Publisher :: BMC, 2018.
Abstract: Abstract Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation of genes in this pathway are hypothesized to affect this common condition. Methods We analyzed the coding regions of LEP, MC4R, MRAP2 and BDNF in 185 children with SNS (height