Back to Search
Start Over
Hepatitis C Virus (HCV) Infection among Seronegative Patients undergoing Haemodialysis in a Remotely Located Tertiary Care Hospital of Northern India: Value of HCV-RNA and Genotypes
- Source :
- Journal of Clinical and Diagnostic Research, Vol 9, Iss 12, Pp DC10-DC12 (2015)
- Publication Year :
- 2015
- Publisher :
- JCDR Research and Publications Private Limited, 2015.
-
Abstract
- Background: Haemodialysis (HD) patients are at an increased risk of Hepatitis C virus (HCV) infection, which is significantly associated with increased morbidity and mortality. Aim: The aim of this study was to find the prevalence of HCV infection in anti-HCV antibody negative haemodialysis patients by Real-time PCR (RT-PCR) and value of HCV-RNA among seronegative patients undergoing haemodialysis in a remotely located tertiary care hospital. Materials and Methods: A total of 100 chronic renal failure patients on haemodialysis were studied. All the patients were screened for anti-HCV antibodies by ELISA test and for HCVRNA by RT-PCR. Results: The overall prevalence of HCV infection was 32%. Antibody positivity was 30% and HCV-RNA by RT-PCR was detected in 20%. HCV-RNA in seronegative patients was detected in 2.8%. Conclusion: Serological assays (30%) are quite reliable for detecting HCV infection in patients undergoing haemodialysis in our tertiary care hospital. Only a small proportion of them (2.8%) require the documentation of viral genome for current infection.
- Subjects :
- anti-hcv antibodies
elisa
rt-pcr
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 2249782X and 0973709X
- Volume :
- 9
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Clinical and Diagnostic Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2c82384bce4e421f8145e4743f3c0942
- Document Type :
- article
- Full Text :
- https://doi.org/10.7860/JCDR/2015/15310.6952