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Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry

Authors :
Kodange Omkar Tukaram
Shibu Simon
K. Magnus Paul
C. Jayakumar
I. S. Sajitha
T. Vanesa John
Source :
Journal of Veterinary and Animal Sciences, Vol 53, Iss 4, Pp 609-616 (2022)
Publication Year :
2022
Publisher :
Director of Academics and Research, Kerala Veterinary and Animal Sciences University, 2022.

Abstract

The objective of the current study involved assessment of correlation between the expression of oestrogen receptor (ERα) and Ki-67 by immunohistochemistry, in the genital borne neoplasms in 12 postpubertal bitches between 2 to 12 years of age, presented at University Veterinary Hospitals, Kokkalai and Mannuthy. The age group of 5-8 years had the highest incidence of neoplasia (50.00 %) in comparison with other groups. Episiotomy was performed for extraluminal tumours while local excision performed in all intraluminal tumours except canine transmissible venereal tumour (CTVT). A chemotherapeutic regimen involving intravenous infusion of vincristine sulphate at 0.025 mg/kg was administered to bitches with CTVT and squamous cell carcinoma (SCC) until complete remission of the neoplasm. The tumours were histopathologically confirmed as myofibroma (n=6), CTVT (n= 3), leiomyoma (n = 1), SCC (n = 1) and fibroma (n = 1). Immunohistochemical staining of the neoplastic tissues was performed to evaluate ERα and Ki-67 expression status which could aid in estimating the malignancy potential and influence of ERα on the same. Spearman’s rank correlation between the immunohistochemical scores for the expression of ERα and Ki-67 in these tumours was highly significant (p

Details

Language :
English
ISSN :
09710701 and 25820605
Volume :
53
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Journal of Veterinary and Animal Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.2c4cfb77434043d4ae8fabf8149e715e
Document Type :
article
Full Text :
https://doi.org/10.51966/jvas.2022.53.4.609-616