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Phage therapy could be key to conquering persistent bacterial lung infections in children

Authors :
Aye Mya Sithu Shein
Parichart Hongsing
Aisha Khatib
Phatthranit Phattharapornjaroen
Kazuhiko Miyanaga
Longzhu Cui
Kenji Shibuya
Mohan Amarasiri
Peter N. Monk
Anthony Kicic
Tanittha Chatsuwan
Paul G. Higgins
Shuichi Abe
Dhammika Leshan Wannigama
Source :
npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-19 (2024)
Publication Year :
2024
Publisher :
Nature Portfolio, 2024.

Abstract

Abstract Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demonstrating significant therapeutic benefits through various administration routes. Ongoing trials are evaluating its safety and effectiveness against different pathogens. Advancing phage therapy through systematic studies and international collaboration could provide a viable alternative to traditional antibiotics for persistent infections.

Subjects

Subjects :
Microbiology
QR1-502

Details

Language :
English
ISSN :
27318745
Volume :
2
Issue :
1
Database :
Directory of Open Access Journals
Journal :
npj Antimicrobials and Resistance
Publication Type :
Academic Journal
Accession number :
edsdoj.2c3da4b045934d7fa38ac7ae6a5bb348
Document Type :
article
Full Text :
https://doi.org/10.1038/s44259-024-00045-4