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Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

Authors :
Di Yu
Yingying Liang
Claudia Kim
Anbalagan Jaganathan
Donglei Ji
Xinye Han
Xuelan Yang
Yanjie Jia
Ruirui Gu
Chunyu Wang
Qiang Zhang
Ka Lung Cheung
Ming-Ming Zhou
Lei Zeng
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

BRD4-NUT’s bipartite binding and activation of p300 in NUT carcinoma nucleates a feed-forward spread of histone hyperacetylation and chromatin condensation that sustains aberrant pro-proliferation gene transcription and perpetual tumor cell growth.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2b92973a3af04c6f8513cfd7ec585873
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36063-5