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Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators
- Source :
- Asian Journal of Andrology, Vol 25, Iss 2, Pp 158-165 (2023)
- Publication Year :
- 2023
- Publisher :
- Wolters Kluwer Medknow Publications, 2023.
-
Abstract
- Prostate cancer is one of the most common diseases in men worldwide. Surgery, radiation therapy, and hormonal therapy are effective treatments for early-stage prostate cancer. However, the development of castration-resistant prostate cancer has increased the mortality rate of prostate cancer. To develop novel drugs for castration-resistant prostate cancer, the molecular mechanisms of prostate cancer progression must be elucidated. Among the signaling pathways regulating prostate cancer development, recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family (WNT) signaling pathways, mainly that involving WNT5A, in prostate cancer progression and metastasis; however, its role remains controversial. Moreover, chromatin remodelers such as the switch/sucrose nonfermentable (SWI/SNF) complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression changes. Here, we review the roles of noncanonical WNT signaling pathways, chromatin remodelers, and epigenetic enzymes in the development and progression of prostate cancer.
Details
- Language :
- English
- ISSN :
- 1008682X and 17457262
- Volume :
- 25
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Asian Journal of Andrology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2b7e6afe2af6475d949514f4e25134fc
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/aja2022109