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l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat

Authors :
Kanako Matsuoka
Hidenori Akaihata
Junya Hata
Ryo Tanji
Ruriko Honda-Takinami
Akifumi Onagi
Seiji Hoshi
Tomoyuki Koguchi
Yuichi Sato
Masao Kataoka
Soichiro Ogawa
Yoshiyuki Kojima
Source :
Metabolites, Vol 11, Iss 11, p 778 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered l-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.

Details

Language :
English
ISSN :
22181989
Volume :
11
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Metabolites
Publication Type :
Academic Journal
Accession number :
edsdoj.2b71df6b9f5d42908a7009ceffdf67b2
Document Type :
article
Full Text :
https://doi.org/10.3390/metabo11110778