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Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project

Authors :
Sergey Avdeev
Svetlana Rachina
Yuliya Belkova
Roman Kozlov
Ann Versporten
Ines Pauwels
Herman Goossens
Elena Bochanova
Elena Elokhina
Ulyana Portnjagina
Olga Reshetko
Igor Sychev
Darya Strelkova
On behalf of Russian Global-PPS Project Study Group
Source :
Tropical Medicine and Infectious Disease, Vol 7, Iss 5, p 75 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 999 patients in COVID-19 wards in six hospitals surveyed in 2021, 51.3% received antimicrobials (79% in intensive care, 47.5% in medical wards). Systemic antivirals and antibiotics were prescribed to 31% and 35.1% of patients, respectively, and a combination of both to 14.1% of patients. The top antivirals administered were favipiravir (65%), remdesivir (19.2%), and umifenovir (15.8%); the top antibiotics were ceftriaxone (29.7%), levofloxacin (18%), and cefoperazone/sulbactam (10.4%). The vast majority of antibiotics was prescribed for treatment of pneumonia or COVID-19 infection (59.3% and 25.1%, respectively). Treatment was based on biomarker data in 42.7% of patients but was targeted only in 29.6% (6.7% for antibiotics). The rate of non-compliance with guidelines reached 16.6%. Antimicrobial prescribing patterns varied considerably in COVID-19 wards in Russian hospitals with groundlessly high rates of systemic antibiotics. Antimicrobial usage surveillance and stewardship should be applied to inpatient care during the COVID-19 pandemic.

Details

Language :
English
ISSN :
24146366
Volume :
7
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Tropical Medicine and Infectious Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.2b3b4c40fe514ad286a8f902ce92905f
Document Type :
article
Full Text :
https://doi.org/10.3390/tropicalmed7050075