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The Arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: the STOPPIT 2 RCT
- Source :
- Health Technology Assessment, Vol 25, Iss 44 (2021)
- Publication Year :
- 2021
- Publisher :
- NIHR Journals Library, 2021.
-
Abstract
- Background: Preterm birth is common in twins and accounts for significant mortality and morbidity. There are no effective preventative treatments. Some studies have suggested that, in twin pregnancy complicated by a short cervix, the Arabin pessary, which fits around the cervix and can be inserted as an outpatient procedure, reduces preterm birth and prevents neonatal morbidity. Objective: STOPPIT 2 aimed to evaluate the clinical utility of the Arabin cervical pessary in preventing preterm birth in women with a twin pregnancy and a short cervix. Design: STOPPIT 2 was a pragmatic, open label, multicentre randomised controlled trial with two treatment group – the Arabin pessary plus standard care (intervention) and standard care alone (control). Participants were initially recruited into the screening phase of the study, when cervical length was measured. Women with a measured cervical length of ≤ 35 mm were then recruited into the treatment phase of the study. An economic evaluation considered cost-effectiveness and a qualitative substudy explored the experiences of participants and clinicians. Setting: Antenatal clinics in the UK and elsewhere in Europe. Participants: Women with twin pregnancy at
Details
- Language :
- English
- ISSN :
- 13665278 and 20464924
- Volume :
- 25
- Issue :
- 44
- Database :
- Directory of Open Access Journals
- Journal :
- Health Technology Assessment
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2b3478619e9e463599d5a6a7a47c166c
- Document Type :
- article
- Full Text :
- https://doi.org/10.3310/hta25440