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The Arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: the STOPPIT 2 RCT

Authors :
Jane E Norman
John Norrie
Graeme MacLennan
David Cooper
Sonia Whyte
Sushila Chowdhry
Sarah Cunningham-Burley
Aileen R Neilson
Xue W Mei
Joel BE Smith
Andrew Shennan
Stephen C Robson
Steven Thornton
Mark D Kilby
Neil Marlow
Sarah J Stock
Philip R Bennett
Jane Denton
Source :
Health Technology Assessment, Vol 25, Iss 44 (2021)
Publication Year :
2021
Publisher :
NIHR Journals Library, 2021.

Abstract

Background: Preterm birth is common in twins and accounts for significant mortality and morbidity. There are no effective preventative treatments. Some studies have suggested that, in twin pregnancy complicated by a short cervix, the Arabin pessary, which fits around the cervix and can be inserted as an outpatient procedure, reduces preterm birth and prevents neonatal morbidity. Objective: STOPPIT 2 aimed to evaluate the clinical utility of the Arabin cervical pessary in preventing preterm birth in women with a twin pregnancy and a short cervix. Design: STOPPIT 2 was a pragmatic, open label, multicentre randomised controlled trial with two treatment group – the Arabin pessary plus standard care (intervention) and standard care alone (control). Participants were initially recruited into the screening phase of the study, when cervical length was measured. Women with a measured cervical length of ≤ 35 mm were then recruited into the treatment phase of the study. An economic evaluation considered cost-effectiveness and a qualitative substudy explored the experiences of participants and clinicians. Setting: Antenatal clinics in the UK and elsewhere in Europe. Participants: Women with twin pregnancy at

Details

Language :
English
ISSN :
13665278 and 20464924
Volume :
25
Issue :
44
Database :
Directory of Open Access Journals
Journal :
Health Technology Assessment
Publication Type :
Academic Journal
Accession number :
edsdoj.2b3478619e9e463599d5a6a7a47c166c
Document Type :
article
Full Text :
https://doi.org/10.3310/hta25440