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Impact of postsurgical vaginal microbiome on high-risk HPV infection and recurrence risk in patients with cervical cancer and intraepithelial neoplasia: A retrospective study

Authors :
Yan Ma
Lijuan Wan
Ruonan Li
Xixi Chen
Huiyan Wang
Source :
Gynecologic Oncology Reports, Vol 55, Iss , Pp 101506- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Purpose: This study aimed to determine the effect of postsurgical vaginal microbiome (VM) on high-risk human papillomavirus (hrHPV) infection and the risk of disease recurrence in patients surgically treated for cervical cancer (CC) or intraepithelial neoplasia (CIN). Methods: 207 women who underwent surgical treatment for CC or CIN at the Department of Gynecologic Oncology of the First Affiliated Hospital of University of Science and Technology of China from November 2016 to October 2023 were included. The patients’ clinical data, including age, surgical modality, and diagnosis at time of index surgery, were collected retrospectively and analyzed. Associations between postsurgical VM indices, hrHPV infection, cervical cytology, and recurrence were also evaluated. Results: Patient age, surgical modality (whether complete excision of the cervix was performed), and diagnosis at time of index surgery (cervical dysplasia vs. cervical carcinoma) showed no significant association with postsurgical hrHPV infection, cervical cytology, or disease recurrence. However, postsurgical VM imbalance was significantly associated with hrHPV infection status (OR = 4.640, 95 % CI = 2.085–10.460, P

Details

Language :
English
ISSN :
23525789
Volume :
55
Issue :
101506-
Database :
Directory of Open Access Journals
Journal :
Gynecologic Oncology Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.2b217ab7d5c04ca0bf349204f4c4ac06
Document Type :
article
Full Text :
https://doi.org/10.1016/j.gore.2024.101506