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Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production

Authors :
Jongmin Ahn
Yihua Pei
Hee-Sung Chae
Seong-Hwan Kim
Young-Mi Kim
Young Hee Choi
Joongku Lee
Minsun Chang
Yun Seon Song
Roberto Rodriguez
Dong-Chan Oh
Jinwoong Kim
Sangho Choi
Sang Hoon Joo
Young-Won Chin
Source :
Molecules, Vol 23, Iss 2, p 302 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav., using interleukin-6 (IL-6) inhibitory assay in human mast cells (HMC-1), led to the isolation of three new compounds with an unprecedented skeleton in nature (1–3) and three known compounds (4–6). Their structures were elucidated through extensive spectroscopic analysis. The three new compounds were elucidated as two new spiroketones, nitidaones A (1), and B (2) and one new biphenyl analog, nitidaol (3). The known compounds were identified as nordihydroguaiaretic acid (4), 7,3′,4′-tri-O-methylquercetin (5) and ayanin (6). All the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells. Of them, compounds 1, 3–6 showed potent anti-inflammatory activity, with IC50 values of 12.8, 17.5, 14.9, 22.9, and 17.8 µM, respectively.

Details

Language :
English
ISSN :
14203049
Volume :
23
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.2b194e259d01468ab4a824007e753ac4
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules23020302