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Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

Authors :
Xiao-Wei Hong
Yu-Qiang Zhou
Cui-Bing Bai
Nai-Xing Wang
Yalan Xing
Wei Zhang
Yan-Jing Wang
Xing-Wang Lan
Yu Xie
Yi-He Li
Source :
Molecules, Vol 20, Iss 9, Pp 17208-17220 (2015)
Publication Year :
2015
Publisher :
MDPI AG, 2015.

Abstract

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.

Details

Language :
English
ISSN :
14203049
Volume :
20
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.2b12365fbe2b4878a110a580d9cad098
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules200917208