The peculiarities of combined pathology of the upper gastrointestinal tract with allergic dermatoses in children

Background. The recent studies indicate that one of the causes of allergic dermatoses (AD) in children and adults is pathology of the gastrointestinal tract. However, many problems of the emergence of these combinations have not yet been resolved. The purpose of the study was to establish the incidence and the nature of lesions of the upper gastrointestinal tract (UGIT) in children with allergic dermatoses. Materials and methods. On the base of the Chernivtsi Regional Children’s Hospital, 40 children with allergic dermatoses combined with the pathology of the upper gastrointestinal tract and 20 patients with AD, but without the UGIT pathology, aged 3 to 18 years were examined. A clinical and laboratory studies were conducted twice (routine clinical tests, chamber scratch test with non-infectious allergens during AD remission), as well as fibrogastroduodenoscopy, ultrasound, pH-measuring biochemical blood tests (alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutaminetransferase (GGTP), alkaline phosphatase, cholesterol), identification of H.pylori. Results. It was indicated that out of 40 examined children with AD, 30 (75 %) persons had various lesions of the esophagus, stomach and duodenum. In 10 (25 %) children, the functional changes, such as duodenogastral reflex (70 %) and failure of the cardia (30 %), were detected. A multiple nature of reflux was observed in 85.7 % of children with chronic gastroduodenitis and in 100 % of children with esophagitis and duodenal ulcer disease. The contamination with H.pylori was detected in 72.5 % of cases. The increased activity of ALT and AST, GGTP, alkaline phosphatase and serum cholesterol was established. Conclusion. In 75 % of children with allergic dermatoses, an organic pathology of the upper gastrointestinal tract was diagnosed, thus, a gastroenterological examination should be recommended to all patients.