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Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

Authors :
Giacinto Asprella Libonati
Antonello Leone
Salvatore Martellucci
Andrea Gallo
Roberto Albera
Sergio Lucisano
Maurizio Bavazzano
Giuseppe Chiarella
Pasquale Viola
Francesco Galletti
Francesco Freni
Francesco Ciodaro
Vincenzo Marcelli
Giuseppe Tortoriello
Leonardo Scotto di Santillo
Pasqualina Maria Picciotti
Jacopo Galli
Silvano Vitale
Nicola Quaranta
Giada Cavallaro
Paolo Gamba
Roberto Teggi
Iacopo Cangiano
Mario Faralli
Annalisa Barboni
Aldo Messina
Giusi Graziano
Source :
Audiology Research, Vol 12, Iss 4, Pp 445-456 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Benign paroxysmal positional vertigo (BPPV) usually has a favorable course, although it is possible to observe BPPV with a high recurrence rate. Previous studies suggested that vitamin D deficiency might affect BPPV recurrences, and oxidative stress might play a complementary role in BPPV pathogenesis. This multicentric trial aimed to evaluate the effectiveness of oral nutritional supplementation with a compound of alpha-lipoic acid, Carnosine, and Zinc (LICA® (Difass International, Coriano (RN), Italy)), vitamins of group B and vitamin D in preventing BPPV recurrences. A total of 128 patients with high recurrence-BPPV were randomized in three arms: Arm 1 consisted of subjects with “insufficient” or “deficient” vitamin D blood levels, treated with daily oral supplementation of LICA®, vitamins of group B and vitamin D3 (800 UI), Arm 2 included BPPV subjects with “sufficient” vitamin D who did not receive any nutritional support, and Arm 3 included subjects with a “sufficient” serum concentration of vitamin D who received supplementation with a compound of LICA® and Curcumin. After six months of follow-up, a significant reduction of BPPV relapses compared to the baseline was found only in Arm 1 (−2.32, 95% CI: 3.41–1.62, p-value < 0.0001). Study results suggested that oral nutritional supplementation with vitamin D3 plus antioxidants can prevent relapses in patients suffering from high recurrence-BPPV.

Details

Language :
English
ISSN :
12040045 and 20394349
Volume :
12
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Audiology Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2b010390a6644399ba6f80df6840c8c4
Document Type :
article
Full Text :
https://doi.org/10.3390/audiolres12040045