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Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
- Source :
- iScience, Vol 26, Iss 8, Pp 107336- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- Summary: To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate, 38%; high, 45%). While these subgroups varied by age, sex, and racial-ethnic distribution (p 0.05). After accounting for sex, age, and race-ethnicity, the CoUD subgroup with high PSA had higher odds of antisocial personality disorder (OR = 21.96 vs. 6.39, difference-p = 8.08✕10−6), agoraphobia (OR = 4.58 vs. 2.05, difference-p = 7.04✕10−4), mixed bipolar episode (OR = 10.36 vs. 2.61, difference-p = 7.04✕10−4), posttraumatic stress disorder (OR = 11.54 vs. 5.86, difference-p = 2.67✕10−4), antidepressant medication use (OR = 13.49 vs. 8.02, difference-p = 1.42✕10−4), and sexually transmitted diseases (OR = 5.92 vs. 3.38, difference-p = 1.81✕10−5) than the low-PSA CoUD subgroup. These findings underscore the importance of modeling PSA severity and comorbidities when examining the clinical, molecular, and neuroimaging correlates of CoUD.
- Subjects :
- Addiction medicine
Socioeconomic status
Science
Subjects
Details
- Language :
- English
- ISSN :
- 25890042
- Volume :
- 26
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- iScience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2aecbf616f04aa380ab9bbc556c6079
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.isci.2023.107336