Cadmium exposure modulates the gut-liver axis in an Alzheimer’s disease mouse model

Angela Zhang et al. report that humanized Apolipoprotein E4 (ApoE4) knock in mice exposed to cadmium had prominent Alzheimer’s Disease-related changes in the makeup of their gut microbiota. They ultimately identify a host genetic-gut microbiome axis susceptible to environmental cadmium insult that may serve as a strong facilitator in cognitive and energy homeostasis.