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Efficacy of chronic statin therapy on major cardiac events after coronary artery bypass grafting: low-dose versus high-dose

Authors :
Ayşegül Kunt
Sedat Özcan
Aslihan Küçüker
Dolunay Odabaşi
Alper Sami Kunt
Source :
Medicinski Glasnik, Vol 12, Iss 2, Pp 196-201 (2015)
Publication Year :
2015
Publisher :
Medical Association of Zenica-Doboj Canton, 2015.

Abstract

Aim To investigate whether chronic statin treatment after coronary artery bypass grafting (CABG) protects patients from major cardiac events and provides percutaneous coronary intervention (PCI) free survival. Methods A total of 232 patients with previous CABG and chronic statin therapy were selected retrospectively and were divided into two groups according to a dosage of atorvastatin per day, e. g., 20 mg or 40 mg. Groups were compared for the major cardiac events and freedom from PCI by Kaplan Meier analysis as the primary end point. Patency of grafts including left internal thoracic artery (LITA) and saphenous vein (SVG) and progression of non-grafted native vessel disease were also evaluated as secondary end points. Results Cardiac mortality, periprocedural myocardial infarction (MI), target vessel revascularization and percutaneous coronary intervention free survival were as follows: 2.9% versus 2.1% (p=1.000); 16.1% versus 21.1% (p=0.331); 56.93% versus 52.63% (p>0.005); 58.4% versus 63.2% (log-rank test; p= 0.347) in atorvastatin 20 mg and atorvastatin 40 mg groups, respectively. However, these results were not statistically significant between two groups (p>0.005). Patency of openness of grafts including LITA and SVG and progression of non-grafted native vessel disease were similar between groups (p=0.112, p=0.779, p=0.379 and p=0.663, respectively). Conclusion Low-dose long-term statin treatment had similar outcomes on major cardiac events and identical rate of freedom from percutaneous coronary intervention after coronary artery bypass grafting compared with high-dose long-term statin treatment. It is better to start from low dose statin treatment after surgical interventions.

Details

Language :
English
ISSN :
18400132 and 18402445
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Medicinski Glasnik
Publication Type :
Academic Journal
Accession number :
edsdoj.2ab75091834a4c0db2c99b525a682682
Document Type :
article
Full Text :
https://doi.org/10.17392/795-15