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Activated B-cell signet ring lymphoma: A case report and a comparative review of the literature
- Source :
- Human Pathology Reports, Vol 30, Iss , Pp 300682- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Signet ring cell lymphoma is an exceedingly rare subtype of non-Hodgkin lymphoma that was originally thought to be a morphologic variant of follicular lymphoma. To date, 56 cases have been reported, with the majority occurring in lymph nodes and bone marrow. Herein, we report a case of a 37-year-old female who presented with a left inguinal mass and high suspicion of lymphoma that was rendered on MRI. A successful ultrasound-guided core biopsy was performed. Pathologic examination revealed a diffuse large B-cell lymphoma (DLBCL) with unique signet ring histology and post-germinal center phenotype. In-situ hybridization showed an isolated BCL-6 gene rearrangement and confirmed the absence of a double-hit phenotype. This case would be situated as the second case of activated B-cell (ABC) signet ring lymphoma and the first case to arise in this anatomic location. The patient recently initiated therapy with a standard six-cycle regimen of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).
- Subjects :
- DLBCL
Activated B-cell
Lymphoma
Signet-ring
Pathology
RB1-214
Subjects
Details
- Language :
- English
- ISSN :
- 2772736X
- Volume :
- 30
- Issue :
- 300682-
- Database :
- Directory of Open Access Journals
- Journal :
- Human Pathology Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2aa8a58af26440ee819ec9c8961a84ba
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.hpr.2022.300682