Gestational age‐related changes in relaxation times of neonatal brain by quantitative synthetic magnetic resonance imaging

Abstract Objective This study aimed to explore the correlation between T1 and T2 relaxation times of synthetic MRI (SyMRI) and gestational age (GA) in each hemisphere of preterm and term newborns at the initial 28 days of birth. Methods Seventy preterm and full‐term infants were prospectively included in this study. All subjects completed 3.0 T routine MRI and SyMRI (MAGiC) one‐stop scanning within 28 days of birth (aged 34–42 W at examination). The SyMRI postprocessing software (v8.0.4) was used to measure the T1 and T2 relaxation values of each brain region. The linear regression equations of quantitative relaxation values with GA were established to compare the variation speed in each brain region. Results A significant linear and negative correlation was found between relaxation times and GA in the neonate cerebral cortex and subcortical gray and white matter regions (All p