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Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles

Authors :
Ming Yuan Li
Trupti Shivaprasad Naik
Lewis Yu Lam Siu
Oreste Acuto
Eric Spooner
Peigang Wang
Xiaohan Yang
Yongping Lin
Roberto Bruzzone
Joseph Ashour
Matthew J Evans
Sumana Sanyal
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Egress of flaviviruses and involved host pathways are not well understood. Here, the authors show that Lyn is a critical host kinase for Dengue and Zika virus egress resulting in infectious virus progenies within autophagosome-derived vesicles, which might help the virus to evade antibody responses.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2a8dfb38e6a44f7b5bd39634f7cb40d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-19028-w