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Significant differe nces in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

Authors :
Raquel Ajub Moyses
Rossana Verónica Mendoza López
Patrícia Maluf Cury
Sheila Aparecida Coelho Siqueira
Otávio Alberto Curioni
José Francisco de Gois Filho
David Livingstone Alves Figueiredo
Eloiza Helena Tajara
Pedro Michaluart Jr
Source :
Clinics, Vol 68, Iss 6, Pp 738-744 (2013)
Publication Year :
2013
Publisher :
Elsevier España, 2013.

Abstract

OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: The patients who smoked and drank were younger, and those who smoked were leaner than the other patients, regardless of alcohol consumption. The non-smokers/non-drinkers were typically elderly white females who had more differentiated oral cavity cancers and fewer first-degree relatives who smoked. The patients who drank presented significantly more frequent nodal metastasis, and those who smoked presented less-differentiated tumors. CONCLUSIONS: The patients with squamous cell carcinoma of the head and neck demonstrated demographic, clinical, and pathological features that were markedly different according to their smoking and drinking habits. A subset of elderly females who had oral cavity cancer and had never smoked or consumed alcohol was notable. Alcohol consumption seemed to be related to nodal metastasis, whereas smoking correlated with the degree of differentiation.

Details

Language :
English
ISSN :
18075932 and 19805322
Volume :
68
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Clinics
Publication Type :
Academic Journal
Accession number :
edsdoj.2a85e2806058434caaff89eeab53794e
Document Type :
article