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Clinical interpretation of serum hepcidin-25 in inflammation and renal dysfunction
- Source :
- Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 24, Iss , Pp 43-49 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Introduction: Hepcidin is a hormone that regulates systemic iron homeostasis. Serum hepcidin levels are under the influence of various stimuli, particularly inflammation and renal dysfunction. The measurement of hepcidin in circulation is a potentially useful clinical tool in the diagnosis, monitoring and treatment of iron metabolism disorder, although clinical interpretation of hepcidin level remains difficult. We evaluated he diagnostic potential and limitations of hepcidin-25 by investigating its relationship with iron and hematological indices, inflammation, and renal dysfunction. Methods: This retrospective study included 220 adult patients not requiring dialysis. Variations of biologically active hepcidin-25 were examined using a mass spectrometry-based assay in various inflammatory and renal states. The log[hepcidin]:log[ferritin] ratio was calculated as an hepcidin index. Results: In 220 adult patients not requiring dialysis, variation in hepcidin-25 level was significantly larger once CRP exceeded 10 mg/l (p 10 mg/l) and/or severe renal dysfunction (eGFR
- Subjects :
- Biomarker
Hepcidin
Iron metabolism
Diagnostic utility
Medical technology
R855-855.5
Subjects
Details
- Language :
- English
- ISSN :
- 2667145X
- Volume :
- 24
- Issue :
- 43-49
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Mass Spectrometry and Advances in the Clinical Lab
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2a6e102744f140bd9b18fe83da29b0e9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jmsacl.2022.03.002