Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells

Authors :: Yan Ma
Yizhen Shi
Xiaoting Zou
Qiujue Wu
Jianping Wang
Source :: Poultry Science, Vol 99, Iss 11, Pp 5802-5813 (2020)
Publication Year :: 2020
Publisher :: Elsevier, 2020.
Abstract: Mercuric chloride (HgCl2) is a serious environmental toxicant. So far, the toxicity mechanism of HgCl2 in chicken embryonic kidney (CEK) cells is not still fully understood. In this study, the possible molecular mechanisms of HgCl2 on apoptosis of CEK cells were investigated. Results showed that the cell morphology changed, and cell viability was significantly decreased (P

Subjects :: apoptosis
chicken embryonic kidney cell
endoplasmic reticulum stress
mercuric chloride
PERK-ATF4-CHOP pathway
Animal culture
SF1-1100

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