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Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

Authors :
Marina Betancor
Belén Marín
Alicia Otero
Carlos Hedman
Antonio Romero
Tomás Barrio
Eloisa Sevilla
Jean-Yves Douet
Alvina Huor
Juan José Badiola
Olivier Andréoletti
Rosa Bolea
Source :
Veterinary Research, Vol 54, Iss 1, Pp 1-7 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with atypical scrapie. Animals were euthanized without clinical signs of prion disease and tested negative for PrPSc accumulation by immunohistochemistry and western blotting. However, an emergence of BSE-like prion seeding activity was detected during in vitro propagation of brain samples from the inoculated animals. These findings suggest that atypical scrapie may represent a potential source of BSE infection in cattle.

Details

Language :
English
ISSN :
12979716
Volume :
54
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Veterinary Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2a677dd837164793b30505a9a15f2807
Document Type :
article
Full Text :
https://doi.org/10.1186/s13567-023-01225-2