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Potential role of tocilizumab in severe gastrointestinal barrier damage after CAR T-cell therapy
- Source :
- Journal of Microbiology, Immunology and Infection, Vol 54, Iss 2, Pp 327-330 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- We report a septicemia and disseminated candidiasis due to delayed gastrointestinal mucosae repair in a patient treated with tocilizumab after anti-CD19 CAR T-cell therapy. Tocilizumab could have inhibited intestinal tissue repair and furthered bacteria translocation leading to the invasion of intestinal mucosa by yeasts as IL-6 is known to be involved in mucosal wound healing.
- Subjects :
- CAR T-cell
Il-6
tocilizumab
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 16841182
- Volume :
- 54
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Microbiology, Immunology and Infection
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2a65ce551cf44b5f82905d7c384e4549
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jmii.2021.02.006