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Hypoglycemic, antidiabetic and toxicological evaluation of leaf extract of Xylopia parviflora (A. rich.) Benth

Authors :
Farouk Adedeji Oladoja
Emmanuel S. Irokosu
Elijah O. Oyinloye
Akanji A. Murtala
Marcus D. Ayoola
Aderonke A. Aderinola
Gift Crucifix Pender
Ololade A. Popoola
Source :
Pharmacological Research - Modern Chinese Medicine, Vol 10, Iss , Pp 100358- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Background: Almost all Xylopia species have a long history of being used therapeutically in China due to their potent antioxidant properties. Xylopia parviflora (X. parviflora) is a relatively novel plant comprised mainly of beta-pinene, which has a rich history in Chinese medicine and is a principal active constituent in numerous Chinese herbs such as Rakkyo, the Chinese onions, Huasi Baidu Fang and Ru Xiang which are all native to China. Objective: The study evaluated the antidiabetic potentials of the methanol leaf extract of X. parviflora and its toxicity profile. Methods: A modified version of the OECD guidelines was used to conduct acute and sub-chronic toxicity tests on the plant extract. The extract's effects on glucose, haematological, and biochemical components were evaluated using standard procedures. Using glibenclamide (10 mg/kg) and distilled water as positive and negative controls, the extract was tested for its antidiabetic activity in diabetic rats with streptozotocin induction at 50, 150, and 300 mg/kg for 28 days. Furthermore, vital organs underwent histopathological examination. Analysis of Variance (ANOVA) and the Dunnett multiple comparison tests were used for the statistical analysis, with a significance level of p

Details

Language :
English
ISSN :
26671425
Volume :
10
Issue :
100358-
Database :
Directory of Open Access Journals
Journal :
Pharmacological Research - Modern Chinese Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.2a4bbfb035ea474689447c522fa9f397
Document Type :
article
Full Text :
https://doi.org/10.1016/j.prmcm.2024.100358