Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma

Juan Feng,1,2 Yuting Zhan,1 Yuting Zhang,1 Hongmei Zheng,1 Weiyuan Wang,3 Songqing Fan1 1Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Clinical Laboratory of Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, People’s Republic of China; 3Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Songqing FanDepartment of Pathology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, People’s Republic of ChinaEmail songqingfan@csu.edu.cnBackground: Heat shock proteins (HSPs) are a large family of chaperones implicating in occurrence and progression of tumor. In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. HSP70 is also an important part of this family and whether the alterations of HSP10 and HSP70 expression and their common expression correlates with carcinogenesis and progression of nasopharyngeal carcinoma (NPC) has not been reported.Method: In this study, we investigate the correlation between the expression of HSP10 and HSP70 and clinicopathological characteristics in NPC by immunohistochemistry (IHC).Results: Results indicated that positive expression of HSP10 and HSP70 was higher in NPC tissues (both P